Ethyl 2-amino-4-methylthiazole-5-carboxylate → HCID 10158399, compound

HRID 1245657Notes

Reaction equation

HRID 1245657 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22]([NH:1][C:2]1[S:3][C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:7])[N:6]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylateHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 10158399HCID 10158399, compound

Procedure

This compound was prepared from ethyl 2-amino-4-methylthiazole-5-carboxylate and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described for EXAMPLE 30. Yield 254 mg, 62%: 1H NMR (DMSO) δ 7.64 (d, 1H), 7.53 (d, 1H), 4.22 (q, 2H), 2.67 (s, 3H), 2.41 (s, 3H), 1.25 (t, 3H); MS-ES (neg) In/z 407.1.

Sources & evidence

ORD record
ord-3e40ed7a5e14422990b5a4a8536fcace
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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