Trifluoroacetic acid → HCID 21914374, compound

HRID 1245860Notes

Reaction equation

HRID 1245860 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[S:6][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH:20]2[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3].FC(F)(F)C(O)=O>ClCCl>[NH2:1][C:2]([NH:4][C:5]1[S:6][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH:20]2[CH2:24][CH2:23][NH:22][CH2:21]2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21914299HCID 21914299, compound

Product 1

HCID 21914374HCID 21914374, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[(Aminocarbonyl)amino]-5-{2-[(1-tert-butyloxycarbonylpyrrolidin-3-yl)oxy]phenyl}-3-thiophenecarboxamide (200 mg) was suspended in dichloromethane (30 ml) and trifluoroacetic acid (5 ml) was added. The mixture was stirred for 1 h, followed by concentration in vacuo. The product was treated with 38% aqueous ammonia and then isolated by filtration as a brown powder (98 mg).

Workup

  1. concentrationfollowed by concentration in vacuo
  2. additionThe product was treated with 38% aqueous ammonia

Sources & evidence

ORD record
ord-b403a937c699437aa04ac0103b6c682e
Source dataset
uspto-grants-2006_10
Patent number
US07125896B2

Reaction notes

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