Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluoropiperidine hydrochloride | HCID 2759158 | — |
| Reactant | 1-bromo-2-(2-chloroethoxy)benzene | HCID 2779027 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21914295 | HCID 21914295 | 33.2% |
Reaction Steps
A mixture of 1-bromo-2-(2-chloroethoxy)benzene (2.35 g), 4-fluoropiperidine hydrochloride (1.54 g), potassium carbonate (4.06 g) and potassium iodide (0.83 g) in dimethylformamide (20 ml) was heated at 80° C. for 18 h. After evaporation, the residue was partitioned between ethyl acetate and water. The solvent phase was washed (brine), dried and evaporated to give an oil (1.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07125896B2 |
|---|
| Source dataset | uspto-grants-2006_10 |
|---|
| ORD ID | ord-24fcf650e6e24c0fb4c7937b5076ece4 |
|---|
| Source note | uspto-grants-2006_10 |
|---|
