Potassium Iodide → HCID 21914295, compound

HRID 1245868Notes

Reaction equation

HRID 1245868 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10]Cl.Cl.[F:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10][N:17]1[CH2:18][CH2:19][CH:14]([F:13])[CH2:15][CH2:16]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 27591584-Fluoropiperidine hydrochlorideHCID 27790271-bromo-2-(2-chloroethoxy)benzene

Product 1

HCID 21914295HCID 21914295, compoundYield 33.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1-bromo-2-(2-chloroethoxy)benzene (2.35 g), 4-fluoropiperidine hydrochloride (1.54 g), potassium carbonate (4.06 g) and potassium iodide (0.83 g) in dimethylformamide (20 ml) was heated at 80° C. for 18 h. After evaporation, the residue was partitioned between ethyl acetate and water. The solvent phase was washed (brine), dried and evaporated to give an oil (1.0 g).

Workup

  1. customAfter evaporation
  2. customthe residue was partitioned between ethyl acetate and water
  3. washThe solvent phase was washed (brine)
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-24fcf650e6e24c0fb4c7937b5076ece4
Source dataset
uspto-grants-2006_10
Patent number
US07125896B2

Reaction notes

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