4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-morpholinoethanone

HRID 1245870Notes

Reaction equation

HRID 1245870 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:10]>C1(C)C=CC=CC=1>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[CH2:8][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 8083Morpholine

Product 1

HCID 4108821-(4-Bromophenyl)-2-morpholinoethanoneYield 101.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

Morpholine (4.35 g) in dry toluene (8 ml) was stirred during the addition of aliquots of 2-bromo-1-(4-bromophenyl)ethanone (6.95 g) in dry toluene (70 ml). The resulting precipitate was removed by filtration and the filtrate evaporated to give the product (J. Amer. Chem. Soc., 1940, 62, 2882) as a pale yellow solid (7.2 g).

Workup

  1. customThe resulting precipitate was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-0da871f3069a4a07b9e014cbe6805ccb
Source dataset
uspto-grants-2006_10
Patent number
US07125896B2

Reaction notes

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