Tetrahydrofuran → N-[4-Chloro-2-(2,2,2-trifluoroacetyl)phenyl]-2,2-dimethylpropanamide

HRID 124593Notes

Reaction equation

[CH2:15]([Li:16])[CH2:17][CH2:18][CH3:19].[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9]([C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[cH:6][cH:7]1.[F:20][C:21]([C:22](=[O:23])[O:24][CH2:25][CH3:26])([F:27])[F:28].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9]([C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[c:6]([C:22]([C:21]([F:20])([F:27])[F:28])=[O:23])[cH:7]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 9794Ethyl trifluoroacetate

HCID 182511Propanamide, N-(4-chlorophenyl)-2,2-dimethyl-

HCID 178418339Butyllithium

Product 1

HCID 46838663N-[4-Chloro-2-(2,2,2-trifluoroacetyl)phenyl]-2,2-dimethylpropanamide

Sources & evidence

ORD record: ord-d128549ed783427ea400ca7c7620f707
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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