HCID 4777742, compound → HCID 10035419, compound

HRID 1245998Notes

Reaction equation

HRID 1245998 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11]CC3C=CC=CC=3)=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:19](=[O:21])[NH2:20]>CO.[Pd]>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([OH:11])=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:19](=[O:21])[NH2:20]

Participants

4

Reactant 1

HCID 4777742HCID 4777742, compound

Product 1

HCID 10035419HCID 10035419, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-methyl-2-carbamoyl-5-benzyloxy-1H-indole (1.94 g; 6.96 mmol) and 10% Pd/C (0.5 g) in methanol (100 ml) was hydrogenated for 2 hours. After filtration of the catalyst on celite, the filtrate was evaporated to give 1-methyl-2-carbamoyl-5-hydroxy-1H-indole.

Workup

  1. filtrationAfter filtration of the catalyst on celite
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-9b84bcdd5cde4b7da37c34d44db5ee54
Source dataset
uspto-grants-2006_10
Patent number
US07125906B2

Reaction notes

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