HCID 4777811, compound → HCID 21915685, compound

HRID 1246000Notes

Reaction equation

HRID 1246000 reaction equation
[C:1]([C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([O:13]CC1C=CC=CC=1)=[CH:8][CH:7]=2)(=[O:3])[NH2:2]>CO.[Pd]>[C:1]([C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([OH:13])=[CH:8][CH:7]=2)(=[O:3])[NH2:2]

Participants

4

Reactant 1

HCID 4777811HCID 4777811, compound

Product 1

HCID 21915685HCID 21915685, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-Carbamoyl-5-benzyloxy-1H-indole (1 g; 3.35 mmol) in solution in methanol (60 ml) was hydrogenated on 10% Pd/C (0.28 g) for 2 hours. After filtration on celite the solvent was evaporated to give 2-carbamoyl-5-hydroxy-1H-indole which was used in the next step without further purification.

Workup

  1. filtrationAfter filtration on celite the solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-45a0c372862440a596511110a38db176
Source dataset
uspto-grants-2006_10
Patent number
US07125906B2

Reaction notes

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