6-Phenyl-1,3-dihydro-indol-2-one → 3-Methyl-5-(2-oxo-6-phenyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic Acid (3-diethylaminopropyl)amide

HRID 1246094Notes

Reaction equation

HRID 1246094 reaction equation
[C:1]1([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][C:12](=[O:16])[NH:13]3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([N:19]([CH2:34][CH3:35])[CH2:20][CH2:21][CH2:22][NH:23][C:24]([C:26]1[NH:27][C:28]([CH:32]=O)=[CH:29][C:30]=1[CH3:31])=[O:25])[CH3:18]>>[CH2:34]([N:19]([CH2:17][CH3:18])[CH2:20][CH2:21][CH2:22][NH:23][C:24]([C:26]1[NH:27][C:28]([CH:32]=[C:11]2[C:10]3[C:14](=[CH:15][C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[CH:8][CH:9]=3)[NH:13][C:12]2=[O:16])=[CH:29][C:30]=1[CH3:31])=[O:25])[CH3:35]

Participants

3

Reactant 2

HCID 105363846-Phenyl-1,3-dihydro-indol-2-oneHCID 865861965-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl) amide

Product 1

HCID 672811273-Methyl-5-(2-oxo-6-phenyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic Acid (3-diethylaminopropyl)amide

Procedure

6-Phenyl-1,3-dihydroindol-2-one (105 mg, 0.5 mmol) was condensed with 5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid (3-diethylaminopropyl)amide to give 67.8 (30%) of the title compound.

Sources & evidence

ORD record
ord-c97850dad1e640f3be7c1040606a58ea
Source dataset
uspto-grants-2006_10
Patent number
US07125905B2

Reaction notes

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