Trifluoroacetic acid → HCID 23557283, compound

HRID 1246250Notes

Reaction equation

HRID 1246250 reaction equation
[CH3:1][O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[CH:6]=[CH:7]/[CH2:8][CH:9]([C:17]([O:19]C(C)(C)C)=[O:18])[C:10]([O:12]C(C)(C)C)=[O:11].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[CH:6]=[CH:7]/[CH2:8][CH:9]([C:10]([OH:12])=[O:11])[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23557315HCID 23557315, compound

Product 1

HCID 23557283HCID 23557283, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 40 (200 mg, 0.59 mmol) in CH2Cl2 (10 mL) was added TFA (1 mL). The reaction was allowed to proceed overnight. Volatiles were removed under reduced pressure to leave 41 as a white solid (112 mg, 0.49 mmol, 83%). 1H-NMR (CD3OD, 400 MHz) δ 7.11 (dd, 1H), 6.33 (dd, 1H), 6.16 (m, 1H), 5.81 (d, 1H), 3.76 (s, 3H), 3.15 (t, 1H), 2.70 (t, 2H).

Workup

  1. customVolatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-30e363d2e9154848a7d5f2f8a640a1fe
Source dataset
uspto-grants-2006_10
Patent number
US07126001B2

Reaction notes

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