HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-[2-(5-Chloro-2-phenylbenzo[b]thiophen-3-yl)ethyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride | HCID 12412184 | — |
| Solvent | Water methylene chloride | HCID 21908982 | — |
| Product | N-[2-(5-Chloro-2-phenylbenzo[b]thiophen-3-yl)ethyl]acetamide | HCID 21917005 | — |
Reaction Steps
The compound obtained in Step E is dissolved in a mixture of water/dichloromethane (2/3); 2 eq. of potassium carbonate are then added and 2 eq. acetyl chloride are added dropwise. After stirring for 2 hours at ambient temperature, the 2 phases are separated; the organic phase is washed with 1M HCl and then with water, until the washing waters are neutral, and is then dried over MgSO4 and evaporated. The residue obtained is purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07126012B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-d0ab10287c53468ca9e0261217ed87fb |
| Source note | uspto-grants-2006_10 |