反应详情

A mixture of ethyl 3-bromo-2-oxopropanoate (100 g), thiourea (39 g) and ethanol (500 ml) was refluxed for 2 hours. The reaction mixture was concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-amino-1,3-thiazole-4-carboxylate hydrobromide (116 g).

1. temperaturewas refluxed for 2 hours
2. concentrationThe reaction mixture was concentrated in vacuo
3. customThe crystalline residue was collected
4. washwashed with ethyl acetate