Ethyl bromopyruvate → Ethyl 2-aminothiazole-4-carboxylate hydrobromide

Participants

Reaction Steps

A mixture of ethyl 3-bromo-2-oxopropanoate (100 g), thiourea (39 g) and ethanol (500 ml) was refluxed for 2 hours. The reaction mixture was concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-amino-1,3-thiazole-4-carboxylate hydrobromide (116 g).

Provenance & Evidence