N-[2-[4-(2-CHLOROACETYL)PHENYL]ETHYL]ACETAMIDE → HCID 21914684, compound

HRID 1246449Notes

Reaction equation

HRID 1246449 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:7][CH:6]=1)=O.[NH2:17][C:18]([NH2:20])=[S:19]>C(O)C>[ClH:1].[NH2:20][C:18]1[S:19][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:7][CH:6]=2)[N:17]=1

Participants

4

Reactant 2

HCID 2468242N-[2-[4-(2-CHLOROACETYL)PHENYL]ETHYL]ACETAMIDEHCID 2723790Thiourea

Product 1

HCID 21914684HCID 21914684, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-{2-[4-(2-Chloroacetyl)phenyl]ethyl}acetamide (1.06 g) and thiourea (505 mg) were dissolved in ethanol (20 mL). The mixture was refluxed for 1 hour and allowed to cool to room temperature. The white solid was collected with filtration and washed with ethanol to give N-{2-[4-(2-amino-1,3-thiazol-4-yl)phenyl]ethyl}acetamide hydrochloride (1.19 g, 90.4%).

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. filtrationThe white solid was collected with filtration
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-b10eb8a6261e4fcda0297c8253564d85
Source dataset
uspto-grants-2006_10
Patent number
US07125901B2

Reaction notes

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