Hydrochloric Acid → HCID 178474441, compound

HRID 1246462Notes

Reaction equation

HRID 1246462 reaction equation
[C:1]([NH:4][C:5]1[S:6][C:7]([Br:36])=[C:8]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][CH:19]([NH:28]C(=O)OC(C)(C)C)[NH:20]C(=O)OC(C)(C)C)=[CH:14][CH:13]=2)[N:9]=1)(=[O:3])[CH3:2].[ClH:37]>O1CCOCC1>[ClH:37].[NH2:28][C:19]([NH:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][CH2:10][C:8]2[N:9]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[S:6][C:7]=2[Br:36])=[CH:13][CH:14]=1)=[NH:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86595594Di-tert-butyl ([(4-{2-[2-(acetylamino)-5-bromo-1,3-thiazol-4-yl]ethyl}phenyl)amino]methylidene}biscarbamate

Product 1

HCID 178474441HCID 178474441, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Di-tert-butyl {[(4-{2-[2-(acetylamino)-5-bromo-1,3-thiazol-4-yl]ethyl}phenyl)amino]methylidene}biscarbamate (113 mg) and 4N hydrochloric acid in 1,4-dioxane solution (2 ml) were combined under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 24 hours. The solvent was removed in vacuo. The residue was washed with ethyl acetate to give N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-bromo-1,3-thiazol-2-yl}acetamide hydrochloride (16.8 mg) as a pale yellow amorphous solid.

Workup

  1. customThe solvent was removed in vacuo
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-33f28c98ec3746d7a9d34aaf243aefee
Source dataset
uspto-grants-2006_10
Patent number
US07125901B2

Reaction notes

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