Hydrochloric Acid → HCID 178474434, compound

HRID 1246471Notes

Reaction equation

HRID 1246471 reaction equation
C(OC(=O)[NH:7][CH:8]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]2[N:28]=[C:29]([NH:32][C:33](=[O:35])[CH3:34])[S:30][CH:31]=2)=[CH:21][CH:20]=1)[NH:9]C(=O)OC(C)(C)C)(C)(C)C.[ClH:37]>ClCCl.O1CCOCC1>[ClH:37].[NH2:9][C:8]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]2[N:28]=[C:29]([NH:32][C:33](=[O:35])[CH3:34])[S:30][CH:31]=2)=[CH:21][CH:20]=1)=[NH:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131726004Di-tert-butyl{((4-{2-(2-(acetylamino)-1,3-thiazol-4-yl]ethyl}benzyl)amino]methylidene}biscarbamate

Product 1

HCID 178474434HCID 178474434, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of di-tert-butyl{[(4-{2-[2-(acetylamino)-1,3-thiazol-4-yl]ethyl}benzyl)amino]methylidene}biscarbamate (20 mg), dichloromethane (2 drops) and 4N hydrogen chloride in 1,4-dioxane (0.5 ml) was stirred for 15 hours. The precipitated crystals were filtered and washed with 1,4-dioxane to give N-(4-{2-[4-({[amino(imino)methyl]amino}methyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide hydrochloride (13 mg).

Workup

  1. filtrationThe precipitated crystals were filtered
  2. washwashed with 1,4-dioxane

Sources & evidence

ORD record
ord-bcbf47ae225f425a877088da696f0ef1
Source dataset
uspto-grants-2006_10
Patent number
US07125901B2

Reaction notes

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