Tetrahydrofuran → HCID 86595612, compound

HRID 1246537Notes

Reaction equation

HRID 1246537 reaction equation
C(OC[S:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][C:21](=[O:23])[CH3:22])[S:18][CH:19]=2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(=O)C.C1COCC1.[OH-].[Na+:30]>CO>[C:21]([NH:20][C:17]1[S:18][CH:19]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([S:6]([O-:8])=[O:7])=[CH:14][CH:13]=2)[N:16]=1)(=[O:23])[CH3:22].[Na+:30]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21914948HCID 21914948, compound

Product 1

HCID 86595612HCID 86595612, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

({4-[2-(Acetylamino)-1,3-thiazol-4-yl]phenyl}sulfonyl)methyl acetate (700 mg), THF (8 ml), MeOH (4 ml) and 1N—NaOH (1.98 ml) were combined. The reaction mixture was stirred at r.t. for 1.5 hours, and concentrated in vacuo. The residual solid was washed with ethyl ether to give sodium 4-[2-(acetylamino)-1,3-thiazol-4-yl]phenylsulfinate (731 mg) as a colorless solid.

Workup

  1. concentrationconcentrated in vacuo
  2. washThe residual solid was washed with ethyl ether

Sources & evidence

ORD record
ord-c0528cff041d4a42b47694411191a5a5
Source dataset
uspto-grants-2006_10
Patent number
US07125901B2

Reaction notes

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