3,4-Dichlorophenol → 4-(3,4-Dichlorophenoxy)nicotinaldehyde

HRID 1246629Notes

Reaction equation

HRID 1246629 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:11]1[C:16]([CH:17]=[O:18])=[CH:15][N:14]=[CH:13][CH:12]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[Cl:8])[O:9][C:11]1[C:16]([CH:17]=[O:18])=[CH:15][N:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 72583,4-DichlorophenolHCID 140466744-Chloropyridine-3-carbaldehyde

Product 1

HCID 219046904-(3,4-Dichlorophenoxy)nicotinaldehyde

Procedure

The title compound was prepared according to Preparation 65 starting from 3,4-dichlorophenol and 4-chloronicotinaldehyde (prepared according to D. Albanese, M. Penso, M. Zenoni, Synthesis 1999, 1294–1296); δH (CDCl3, 400 MHz) 6.71 (1H, d), 7.04 (1H, dd), 7.27 (1H, m), 7.55 (1H, d), 8.02 (1H, s), 8.60 (1H, dd), 10.54 (1H, s); MS rn/z268 (MH+).

Sources & evidence

ORD record
ord-6380928bdfb649e4a182385cd4c4c1ae
Source dataset
uspto-grants-2006_10
Patent number
US07129234B2

Reaction notes

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