HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate → Methyl 4-hydroxypiperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate | HCID 12343427 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-hydroxypiperidine-4-carboxylate | HCID 21093366 | — |
Reaction Steps
Methyl 1-benzyl-4-hydroxy-4-piperidinecarboxylate in methanol was treated with Pd(OH)2 (20% on carbon, 500 mg) under a hydrogen atmosphere. The mixture was allowed to stir at room temperature for 12 hours, filtered, and the filtrate was concentrated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129235B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-a2744ea31a0944faae072d239330c164 |
| Source note | uspto-grants-2006_10 |