Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 1246717Notes

Reaction equation

HRID 1246717 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([OH:18])([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[OH:18][C:11]1([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 12343427Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Product 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

Methyl 1-benzyl-4-hydroxy-4-piperidinecarboxylate in methanol was treated with Pd(OH)2 (20% on carbon, 500 mg) under a hydrogen atmosphere. The mixture was allowed to stir at room temperature for 12 hours, filtered, and the filtrate was concentrated under reduced pressure.

Workup

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a2744ea31a0944faae072d239330c164
Source dataset
uspto-grants-2006_10
Patent number
US07129235B2

Reaction notes

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