反应详情

Methyl 3′-(trifluoromethyl)-3,6-dihydro-2H-1,2′-bipyridine-4-carboxylate (15 mL) in THF (30 mL) was treated with 1N NaOH (27 mL) and stirred for 2 hours. The mixture was treated with additional 1N NaOH (16 mL), stirred for 1 hour, treated with 1N NaOH (14.5 mL), and stirred for 1 hour. The mixture was diluted with water and extracted with CH2Cl2. The aqueous layer was then acidified with concentrated HCl and extracted with CHCl3. The organic layer was dried (Na2SO4), filtered, and the filtrate was concentrated under reduced pressure to provide the title compound.

1. stirringstirred for 1 hour
2. stirringstirred for 1 hour
3. extractionextracted with CH2Cl2
4. extractionextracted with CHCl3
5. dry with materialThe organic layer was dried (Na2SO4)
6. filtrationfiltered
7. concentrationthe filtrate was concentrated under reduced pressure