2,5-Diamino-4,6-dichloropyrimidine → 6-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyrimidine-2,4,5-triamine

HRID 1246742Notes

Reaction equation

HRID 1246742 reaction equation
Cl[C:2]1[C:7]([NH2:8])=[C:6]([Cl:9])[N:5]=[C:4]([NH2:10])[N:3]=1.[NH2:11][CH2:12][C:13]1[C:18]([CH3:19])=[C:17]([O:20][CH3:21])[C:16]([CH3:22])=[CH:15][N:14]=1>CCCCO>[Cl:9][C:6]1[N:5]=[C:4]([NH2:10])[N:3]=[C:2]([NH:11][CH2:12][C:13]2[C:18]([CH3:19])=[C:17]([O:20][CH3:21])[C:16]([CH3:22])=[CH:15][N:14]=2)[C:7]=1[NH2:8]

Participants

4

Reactant 2

HCID 3010392,5-Diamino-4,6-dichloropyrimidineHCID 14645997(4-Methoxy-3,5-dimethylpyridin-2-yl)methanamine

Product 1

HCID 582786076-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyrimidine-2,4,5-triamine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 4,6-dichloro-pyrimidine-2,5-diamine and 2-aminomethyl-4-methoxy-3,5-dimethyl-pyridine was heated to reflux in n-BuOH for 3 h, following the general procedure 1. HPLC RT was 3.597 min. 1HNMR (CDCl3) δ 8.22 (s, 1H), 7.12 (br. t, 1H), 4.61 (s, 2H), 4.56–4.55 (d, 2H), 3.80 (s, 3H), 3.00 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H).

Workup

  1. temperaturewas heated

Sources & evidence

ORD record
ord-adf01b6941ea49ab9c7555c080942a52
Source dataset
uspto-grants-2006_10
Patent number
US07129244B2

Reaction notes

Loading…