HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Diamino-4,6-dichloropyrimidine → 6-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyrimidine-2,4,5-triamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Diamino-4,6-dichloropyrimidine | HCID 301039 | — |
| Reactant | (4-Methoxy-3,5-dimethylpyridin-2-yl)methanamine | HCID 14645997 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 6-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyrimidine-2,4,5-triamine | HCID 58278607 | — |
Reaction Steps
A mixture of 4,6-dichloro-pyrimidine-2,5-diamine and 2-aminomethyl-4-methoxy-3,5-dimethyl-pyridine was heated to reflux in n-BuOH for 3 h, following the general procedure 1. HPLC RT was 3.597 min. 1HNMR (CDCl3) δ 8.22 (s, 1H), 7.12 (br. t, 1H), 4.61 (s, 2H), 4.56–4.55 (d, 2H), 3.80 (s, 3H), 3.00 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129244B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-adf01b6941ea49ab9c7555c080942a52 |
| Source note | uspto-grants-2006_10 |