Chlorosuccinimide → HCID 21906156, compound

HRID 1246747Notes

Reaction equation

HRID 1246747 reaction equation
[Cl:1][C:2]1[C:3]2[N:11]=[N:10][N:9]([CH2:12][C:13]3[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=3)[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.C1C(=O)N([Cl:32])C(=O)C1>>[Cl:1][C:2]1[C:3]2[N:11]=[N:10][N:9]([CH2:12][C:13]3[CH:14]=[C:15]([O:23][CH3:24])[C:16]([O:21][CH3:22])=[C:17]([O:19][CH3:20])[C:18]=3[Cl:32])[C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

Participants

3

Reactant 2

HCID 31398ChlorosuccinimideHCID 21906138HCID 21906138, compound

Product 1

HCID 21906156HCID 21906156, compound

Procedure

Chlorination of 7-chloro-3-(3,4,5-trimethoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine) (CF 2137) with NCS (1.5 equivalents) was done following the general procedure 3 to give the title compound: HPLC RT was 6.244 min. 1HNMR (CDCl3): δ 6.53 (s, 1H), 5.70 (s, 2H), 5.48 (s, 2H), 3.89 (s, 3H), 3.87 (s, 3H), 3.75 (s, 3H).

Sources & evidence

ORD record
ord-bfee79f74eec40fb9a7b7febf6e9a599
Source dataset
uspto-grants-2006_10
Patent number
US07129244B2

Reaction notes

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