Triethylamine → HCID 10053073, compound

Participants

Reaction Steps

To a solution of 6-Chloro-9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purine I-(4A-7)c (68 mg, 0.18 mmol) in 1:1 methylene chloride/ethanol (2 ml) was added 1-(4-phenylpiperidin-4-yl)-ethanone (48 mg, 0.2 mmol) and triethylamine (70 μl, 0.5 mmol). The mixture was stirred overnight, concentrated under reduced pressure, and then purified on a Biotage™ Flash 12S column using 5–10% methanol in methylene chloride as eluant to give title compound 29A-1 (77 mg, 78%).

Provenance & Evidence