Triethylamine → HCID 10053073, compound

HRID 1246826Notes

Reaction equation

HRID 1246826 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[Cl:24])[N:6]2[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1.[C:25]1([C:31]2([C:37](=[O:39])[CH3:38])[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(N(CC)CC)C>C(Cl)Cl.C(O)C>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([N:6]2[C:5]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])=[N:4][C:3]3[C:7]2=[N:8][CH:9]=[N:10][C:2]=3[N:34]2[CH2:35][CH2:36][C:31]([C:37](=[O:39])[CH3:38])([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:32][CH2:33]2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1015214-Acetyl-4-phenylpiperidineHCID 219057796-Chloro-8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purine

Product 1

HCID 10053073HCID 10053073, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

To a solution of 6-Chloro-9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purine I-(4A-7)c (68 mg, 0.18 mmol) in 1:1 methylene chloride/ethanol (2 ml) was added 1-(4-phenylpiperidin-4-yl)-ethanone (48 mg, 0.2 mmol) and triethylamine (70 μl, 0.5 mmol). The mixture was stirred overnight, concentrated under reduced pressure, and then purified on a Biotage™ Flash 12S column using 5–10% methanol in methylene chloride as eluant to give title compound 29A-1 (77 mg, 78%).

Workup

  1. concentrationconcentrated under reduced pressure
  2. custompurified on a Biotage™ Flash 12S column

Sources & evidence

ORD record
ord-022ba7a23f724042ad1cf46bccbfc506
Source dataset
uspto-grants-2006_10
Patent number
US07129239B2

Reaction notes

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