D-Proline → HCID 21906766, compound

HRID 1246846Notes

Reaction equation

HRID 1246846 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[O:21][CH3:22])=[C:10]([C:23]([F:26])([F:25])[F:24])[CH:9]=2)[CH:5]=[CH:4][N:3]=1.OC1CCNC1.[NH:33]1[CH2:40][CH2:39][CH2:38][C@@H:34]1[C:35]([OH:37])=[O:36]>>[CH3:22][O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([N:33]3[CH2:40][CH2:39][CH2:38][CH:34]3[C:35]([OH:37])=[O:36])[CH:7]=2)=[CH:9][C:10]=1[C:23]([F:26])([F:25])[F:24]

Participants

4

Reactant 3

HCID 8988D-ProlineHCID 982104-HydroxypyrrolidineHCID 219068092-Chloro-4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 21906766HCID 21906766, compound

Procedure

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with (D)-proline. A yellow solid 100 was obtained (0.0366 g, 78%).

Sources & evidence

ORD record
ord-616b2d5e68b34d4ebfc6e72b779b797b
Source dataset
uspto-grants-2006_10
Patent number
US07129247B2

Reaction notes

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