反应详情

The suspension that consists of 5.0 g (45.8 mmol) of 4-aminophenol, 4.49 g of maleic acid anhydride and 40 ml of acetic acid is refluxed for 3 hours. It is concentrated by evaporation, residual acetic acid is removed azeotropically by repeated distillation with acetic acid, and the residue is purified by chromatography on fine silica gel. 2.83 g (15.0 mmol, 33%) of the title compound is isolated.

1. temperatureis refluxed for 3 hours
2. concentrationIt is concentrated by evaporation, residual acetic acid
3. customis removed azeotropically
4. distillationdistillation with acetic acid
5. customthe residue is purified by chromatography on fine silica gel