HCID 136335136, compound → HCID 136335137, compound

HRID 1247016Notes

Reaction equation

HRID 1247016 reaction equation
[OH:1][C@H:2]([CH3:17])[CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:16])[C:11]=2[N+:13]([O-])=O)[CH:6]=[N:5]1>CO.[Pd]>[NH2:13][C:11]1[C:10]([OH:16])=[CH:9][CH:8]=[C:7]2[C:12]=1[N:4]([CH2:3][C@H:2]([OH:1])[CH3:17])[N:5]=[CH:6]2

Participants

4

Reactant 1

HCID 136335136HCID 136335136, compound

Product 1

HCID 136335137HCID 136335137, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the product from Step B (1.84 g, 7.76 mmol) in methanol (20 mL) was added palladium-on-carbon (100 mg) and this mixture was stirred under a hydrogen atmosphere at room temperature for 4 h. The reaction mixture was filtered (avoiding air) and evaporated to a colorless oil: LC/MS m/z 208. This oil was immediately carried into the next step.

Workup

  1. filtrationThe reaction mixture was filtered (avoiding air)
  2. customevaporated to a colorless oil

Sources & evidence

ORD record
ord-afe78301960041c69747d3302b2f72c9
Source dataset
uspto-grants-2006_10
Patent number
US07129257B1

Reaction notes

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