HCID 86604079, compound → HCID 11658948, compound

HRID 1247019Notes

Reaction equation

HRID 1247019 reaction equation
[N:1]([C@@H:4]([CH3:21])[CH2:5][N:6]1[C:20]2[C:13]3[N:14]=[C:15]([C:17]([NH2:19])=[O:18])[O:16][C:12]=3[CH:11]=[CH:10][C:9]=2[CH:8]=[N:7]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][C@@H:4]([CH3:21])[CH2:5][N:6]1[C:20]2[C:13]3[N:14]=[C:15]([C:17]([NH2:19])=[O:18])[O:16][C:12]=3[CH:11]=[CH:10][C:9]=2[CH:8]=[N:7]1

Participants

4

Reactant 1

HCID 86604079HCID 86604079, compound

Product 1

HCID 11658948HCID 11658948, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the product from Step E (0.18 g, 0.631 mmol) in methanol (10 mL) was added 10% palladium-on-carbon (20 mg). This mixture was maintained under an atmosphere of hydrogen at room temperature for three days. The reaction mixture was filtered and evaporated to a tan solid (0.16 g): mp 60–65° C.; LC/MS m/z 260. Analysis. Calculated for C12H13N5O2.0.5 CH3OH: C, 54.54; H, 5.49; N, 25.44. Found: C, 54.79; H, 5.35; N, 25.29.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated to a tan solid (0.16 g)

Sources & evidence

ORD record
ord-4d282e273c084d158abf4f992261eb64
Source dataset
uspto-grants-2006_10
Patent number
US07129257B1

Reaction notes

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