反应详情

To a mixture of methyl 1-benzylpyrrolidine-3-carboxylate (11.67 g, 50 mmol) and tetrahydrofuran, at 0° C. was added lithium aluminum hydride (3.795 g, 100 mmol). The reaction was warmed to room temperature and refluxed for 24 hours. After cooling to 0° C., the reaction was quenched with saturated sodium sulfate and warmed to room temperature. Tetrahyrofuran (50 mL) and solid sodium sulfate were added to the mixture. After stirring for 1 hour, the mixture was filtered and the filtrate was concentrated and vacuum dried for 3 days to give the title compound as a colorless oil (8.49 g, 88%).

1. temperaturerefluxed for 24 hours
2. temperatureAfter cooling to 0° C.
3. customthe reaction was quenched with saturated sodium sulfate
4. temperaturewarmed to room temperature
5. additionTetrahyrofuran (50 mL) and solid sodium sulfate were added to the mixture
6. filtrationthe mixture was filtered
7. concentrationthe filtrate was concentrated
8. customvacuum dried for 3 days