4-(Aminomethyl)benzonitrile → (RS)-2-(4-benzyloxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide

HRID 1247237Notes

Reaction equation

HRID 1247237 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([O:19][CH3:20])[C:16]([OH:18])=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]([O:19][CH3:20])[C:16]([NH:28][CH2:27][C:26]2[CH:29]=[CH:30][C:23]([C:22]#[N:21])=[CH:24][CH:25]=2)=[O:18])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 692909522-[4-(Benzyloxy)phenyl]-2-methoxyacetic acid

Product 1

HCID 21904879(RS)-2-(4-benzyloxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide

Procedure

(RS)-(4-Benzyloxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile to give (RS)-2-(4-benzyloxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide according to general procedure B. Colorless solid. MS 387.3 ([M+H]+)

Sources & evidence

ORD record
ord-2fc3d717f3764ef1a39d35ccdac423c6
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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