4-(Aminomethyl)benzonitrile → (RS)-2-(3-benzyloxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide

HRID 1247242Notes

Reaction equation

HRID 1247242 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]([O:19][CH3:20])[C:16]([OH:18])=O)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]([O:19][CH3:20])[C:16]([NH:28][CH2:27][C:26]2[CH:29]=[CH:30][C:23]([C:22]#[N:21])=[CH:24][CH:25]=2)=[O:18])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69289061HCID 69289061, compound

Product 1

HCID 21904929(RS)-2-(3-benzyloxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide

Procedure

(RS)-(3-Benzyloxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-2-(3-benzyloxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Light yellow oil.

Sources & evidence

ORD record
ord-e7d6c98ce053485383908db8227808d9
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

Loading…