HCID 69290539, compound → HCID 69288839, compound

HRID 1247251Notes

Reaction equation

HRID 1247251 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:17]([O:21][CH3:22])[C:18]([OH:20])=[O:19])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:17]([O:21][CH3:22])[C:18]([OH:20])=[O:19])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

4

Reactant 1

HCID 69290539HCID 69290539, compound

Product 1

HCID 69288839HCID 69288839, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a stirred solution of (RS)-(3-benzyloxy-4-methoxy-phenyl)-methoxy-acetic acid (0.923 g) at rt in ethanol was added 10% Pd/C. The mixture was then stirred at rt under a hydrogen atmosphere for 17 h. The catalyst was filtered off and washed with dichloromethane. The filtrate was concentrated (rotavapor) to give (RS)-(3-hydroxy-4-methoxy-phenyl)-methoxy-acetic acid (0.642 g) as an orange gum.

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with dichloromethane
  3. concentrationThe filtrate was concentrated (rotavapor)

Sources & evidence

ORD record
ord-3b3e140a229f4937bf827859bba92e6a
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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