2-[4-(Benzyloxy)phenyl]-2-methoxyacetic acid → 2-(4-Hydroxyphenyl)-2-methoxyacetic acid

HRID 1247258Notes

Reaction equation

HRID 1247258 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([O:19][CH3:20])[C:16]([OH:18])=[O:17])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].CCO>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]([O:19][CH3:20])[C:16]([OH:18])=[O:17])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 692909522-[4-(Benzyloxy)phenyl]-2-methoxyacetic acid

Product 1

HCID 189589752-(4-Hydroxyphenyl)-2-methoxyacetic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

(RS)-(4-Benzyloxy-phenyl)-methoxy-acetic acid (example 3.1) was hydrogenated at rt and normal pressure using 10% Pd/C as a catalyst and EtOH as a solvent to give (RS)-(4-hydroxy-phenyl)-methoxy-acetic acid as a light grey solid. MS 181.4 ([M−H]−)

Workup

  1. customwas hydrogenated at rt

Sources & evidence

ORD record
ord-33dd010defb9421e9cf4b3b3299ace92
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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