HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminomethyl)benzonitrile → (Rs)-n-(4-cyano-benzyl)-2-methoxy-2-(4-pyrrolidin-1-yl-phenyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminomethyl)benzonitrile | HCID 82608 | — |
| Reactant | 4-(1-Pyrrolidinyl)benzaldehyde | HCID 104037 | — |
| Reactant | Dioxane Methanol | HCID 21966525 | — |
| Product | (Rs)-n-(4-cyano-benzyl)-2-methoxy-2-(4-pyrrolidin-1-yl-phenyl)-acetamide | HCID 21905106 | — |
Reaction Steps
4-(1-Pyrrolidino)benzaldehyde was reacted according to general procedure A using methanol/dioxane as a solvent. The product of this reaction was subsequently coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-(4-pyrrolidin-1-yl-phenyl)-acetamide. Off-white solid. MS 350.4 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-32c66ff237be47e485c53e9f2b13a167 |
| Source note | uspto-grants-2006_10 |