4-(Aminomethyl)benzonitrile → HCID 21905230, compound

HRID 1247291Notes

Reaction equation

HRID 1247291 reaction equation
C([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:5][CH:4]=1)=O.[NH2:14][CH2:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1.CO.[O:26]1[CH2:31][CH2:30][O:29][CH2:28]C1>>[C:20]([C:19]1[CH:22]=[CH:23][C:16]([CH2:15][NH:14][C:31](=[O:26])[CH:30]([C:3]2[CH:8]=[CH:7][C:6]([N:9]3[CH:13]=[CH:12][N:11]=[CH:10]3)=[CH:5][CH:4]=2)[O:29][CH3:28])=[CH:17][CH:18]=1)#[N:21]

Participants

4

Reactant 3

HCID 826084-(Aminomethyl)benzonitrileHCID 7365304-(1H-imidazol-1-yl)benzaldehydeHCID 21966525Dioxane Methanol

Product 1

HCID 21905230HCID 21905230, compound

Procedure

1-(4-Formylphenyl)-1H-imidazole was reacted according to general procedure A using methanol/dioxane as a solvent. The product of this reaction was subsequently coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(4-imidazol-1-yl-phenyl)-2-methoxy-acetamide. Colorless foam. MS 347.2 ([M+H]+)

Sources & evidence

ORD record
ord-ff044ea5de3c41ee9a0c33ca00621fcf
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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