4-(Aminomethyl)benzonitrile → HCID 21905112, compound

HRID 1247293Notes

Reaction equation

HRID 1247293 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10](C=O)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1.CO.[O:27]1[CH2:32][CH2:31][O:30][CH2:29]C1>>[C:21]([C:20]1[CH:23]=[CH:24][C:17]([CH2:16][NH:15][C:32](=[O:27])[CH:31]([O:30][CH3:29])[C:10]2[CH:9]=[CH:8][C:7]([N:4]3[CH2:3][CH2:2][O:1][CH2:6][CH2:5]3)=[CH:14][CH:13]=2)=[CH:18][CH:19]=1)#[N:22]

Participants

4

Reactant 3

HCID 826084-(Aminomethyl)benzonitrileHCID 2913494-MorpholinobenzaldehydeHCID 21966525Dioxane Methanol

Product 1

HCID 21905112HCID 21905112, compound

Procedure

4-Morpholinobenzaldehyde was reacted according to general procedure A using methanol/dioxane as a solvent. The product of this reaction was subsequently coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-(4-morpholin-4-yl-phenyl)-acetamide. Orange oil. MS 366.2 ([M+H]+)

Sources & evidence

ORD record
ord-7c5cf29ffd8d4365aa8f8e1c867571b5
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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