HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminomethyl)benzonitrile → (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4-methoxy-phenyl)-2-propoxy-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminomethyl)benzonitrile | HCID 82608 | — |
| Reactant | 2-Fluoro-4-methoxybenzaldehyde | HCID 2734873 | — |
| Reactant | n-Propanol dioxane | HCID 67832237 | — |
| Product | (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4-methoxy-phenyl)-2-propoxy-acetamide | HCID 21905254 | — |
Reaction Steps
2-Fluoro-4-methoxybenzaldehyde was reacted according to general procedure A using n-propanol/dioxane as a solvent. The product of this reaction was subsequently coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4-methoxy-phenyl)-2-propoxy-acetamide. Light yellow oil. MS 357.2 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ba6269c2c4a84ada91df67086a928b33 |
| Source note | uspto-grants-2006_10 |