Hydroxyamine hydrochloride → HCID 86593048, compound

HRID 1247360Notes

Reaction equation

HRID 1247360 reaction equation
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=O.Cl.[NH2:18][OH:19].C([O-])(=O)C.[Na+]>C(O)C>[OH:19][N:18]=[CH:1][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 21905435HCID 21905435, compound

Product 1

HCID 86593048HCID 86593048, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In analogy to example 106.2, 4-formyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrile was reacted with hydroxylamine hydrochloride and sodium acetate in ethanol to give 4-(hydroxyimino-methyl)-3-(2,2,2-trifluoro-ethoxy)-benzonitrile as a yellow solid.

Sources & evidence

ORD record
ord-473b5328c271491786a8615a94be310a
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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