反应详情

tert-Butydiphenylchlorosilane (76.8 g) was added over 30 min to a cooled (0° C.) solution of 2,4-difluorophenol (34.6 g) and imidazole (19.9 G) in CH2Cl2 (400 ml). The cooling bath was removed and the reaction mixture was stirred 2 h at rt before washing it with H2O (400 ml), 5% aq. NaHCO3 (300 ml) and brine. The aqueous layers were extracted with two more portions of CH2Cl2 (150 ml). The combined organic layers were dried (Na2SO4) and the solvent was evaporated to obtain 102 g (99%) of tert-butyl-(2,4-difluoro-phenoxy)-diphenyl-silane. Colorless liquid.

1. customThe cooling bath was removed
2. washbefore washing it with H2O (400 ml), 5% aq. NaHCO3 (300 ml) and brine
3. extractionThe aqueous layers were extracted with two more portions of CH2Cl2 (150 ml)
4. dry with materialThe combined organic layers were dried (Na2SO4)
5. customthe solvent was evaporated