(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide → (RS)-N-(4-Cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-methoxy-acetamide

HRID 1247391Notes

Reaction equation

HRID 1247391 reaction equation
FC1C(O)=CC=C(F)C=1C(OC)C(O)=O.[C:16]([C:18]1[CH:40]=[CH:39][C:21]([CH2:22][NH:23][C:24](=[O:38])[CH:25]([C:29]2[C:34]([F:35])=[CH:33][CH:32]=[C:31]([OH:36])[C:30]=2[F:37])[O:26][CH2:27]C)=[CH:20][CH:19]=1)#[N:17]>>[C:16]([C:18]1[CH:19]=[CH:20][C:21]([CH2:22][NH:23][C:24](=[O:38])[CH:25]([C:29]2[C:34]([F:35])=[CH:33][CH:32]=[C:31]([OH:36])[C:30]=2[F:37])[O:26][CH3:27])=[CH:39][CH:40]=1)#[N:17]

Participants

3

Reactant 2

HCID 21905759(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamideHCID 69290134(RS)-(2,6-difluoro-3-hydroxy-phenyl)-methoxy-acetic acid

Product 1

HCID 21905078(RS)-N-(4-Cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-methoxy-acetamide

Procedure

(RS)-N-(4-Cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-methoxy-acetamide was prepared from (RS)-(2,6-difluoro-3-hydroxy-phenyl)-methoxy-acetic acid in analogy to (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide (example 213). White foam. MS 330.8 ([M−H]−).

Sources & evidence

ORD record
ord-57cf153e1a1243ec997b5c5aea30c392
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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