Hydroxyamine hydrochloride → HCID 178468074, compound

HRID 1247401Notes

Reaction equation

[C:1]([C:3]1[CH:29]=[CH:28][C:6]([CH2:7][NH:8][C:9](=[O:27])[CH:10]([C:14]2[C:19]([F:20])=[CH:18][C:17]([C:21]3[O:22][CH:23]=[CH:24][CH:25]=3)=[CH:16][C:15]=2[F:26])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2].Cl.[NH2:31][OH:32]>>[F:20][C:19]1[CH:18]=[C:17]([C:21]2[O:22][CH:23]=[CH:24][CH:25]=2)[CH:16]=[C:15]([F:26])[C:14]=1[CH:10]([O:11][CH2:12][CH3:13])[C:9]([NH:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([C:1](=[NH:2])[NH:31][OH:32])=[CH:29][CH:28]=1)=[O:27]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 21905326HCID 21905326, compound

Product 1

HCID 178468074HCID 178468074, compound

Procedure

In analogy to example 15.5, (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-furan-2-yl-phenyl)-2-ethoxy-acetamide was reacted with hydroxylamine hydrochloride to give (RS)-2-(2,6-difluoro-4-furan-2-yl-phenyl)-2-ethoxy-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide. Colorless solid. MS 430.0 ([M+H]+)

Sources & evidence

ORD record: ord-1e0e8288720244658ea6c5bb7167f7b2
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

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