HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 21904886, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | HCID 21905739 | HCID 21905739 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21904886 | HCID 21904886 | — |
Reaction Steps
In analogy to example 16.4, (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-hydroxy-biphenyl-4-yl)-2-ethoxy-acetamide (example 256.1) was alkylated with 1-chloro-2-dimethylaminoethane hydrochloride and cesium carbonate in DMF to give (RS)-N-(4-cyano-benzyl)-2-[2′-(2-dimethylamino-ethoxy)-3,5-difluoro-biphenyl-4-yl]-2-ethoxy-acetamide. Colorless solid. MS 494.1 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-b2e8247625da40e4a325caf0dd447557 |
| Source note | uspto-grants-2006_10 |