HRID1247405

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID11636816

N,N-Dimethylaminoethyl chloride hydrochloride

C4H11Cl2N

HCID21905739

未命名化合物

PRODUCTS

产物

HCID21904886

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In analogy to example 16.4, (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-hydroxy-biphenyl-4-yl)-2-ethoxy-acetamide (example 256.1) was alkylated with 1-chloro-2-dimethylaminoethane hydrochloride and cesium carbonate in DMF to give (RS)-N-(4-cyano-benzyl)-2-[2′-(2-dimethylamino-ethoxy)-3,5-difluoro-biphenyl-4-yl]-2-ethoxy-acetamide. Colorless solid. MS 494.1 ([M+H]+)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-b2e8247625da40e4a325caf0dd447557
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07129238B2
来源说明: uspto-grants-2006_10

反应SMILES

[C:1]([C:3]1[CH:31]=[CH:30][C:6]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:14]2[C:19]([F:20])=[CH:18][C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[OH:27])=[CH:16][C:15]=2[F:28])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2].Cl.Cl[CH2:34][CH2:35][N:36]([CH3:38])[CH3:37].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:14]2[C:15]([F:28])=[CH:16][C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH2:34][CH2:35][N:36]([CH3:38])[CH3:37])=[CH:18][C:19]=2[F:20])[O:11][CH2:12][CH3:13])=[CH:30][CH:31]=1)#[N:2]