HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoacetamide → HCID 178468072, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoacetamide | HCID 3727 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | HCID 21905739 | HCID 21905739 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178468072 | HCID 178468072 | — |
Reaction Steps
In analogy to example 16.4, (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-hydroxy-biphenyl-4-yl)-2-ethoxy-acetamide (example 256.1) was alkylated with iodoacetamide and cesium carbonate in DMF. The product of this reaction was reacted with hydroxylamine hydrochloride in analogy to example 15.5 to give (RS)-2-(2′-carbamoylmethoxy-3,5-difluoro-biphenyl-4-yl)-2-ethoxy-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide. Colorless solid. MS 513.1 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-d4285d0474544066ad976a82075b2dd4 |
| Source note | uspto-grants-2006_10 |