HRID1247406

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3727

Iodoacetamide

C2H4INO

HCID10796

Cesium carbonate

CCs2O3

HCID443297

未命名化合物

HCID21905739

未命名化合物

PRODUCTS

产物

HCID178468072

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In analogy to example 16.4, (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-hydroxy-biphenyl-4-yl)-2-ethoxy-acetamide (example 256.1) was alkylated with iodoacetamide and cesium carbonate in DMF. The product of this reaction was reacted with hydroxylamine hydrochloride in analogy to example 15.5 to give (RS)-2-(2′-carbamoylmethoxy-3,5-difluoro-biphenyl-4-yl)-2-ethoxy-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide. Colorless solid. MS 513.1 ([M+H]+)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-d4285d0474544066ad976a82075b2dd4
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07129238B2
来源说明: uspto-grants-2006_10

反应SMILES

[C:1]([C:3]1[CH:31]=[CH:30][C:6]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:14]2[C:19]([F:20])=[CH:18][C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[OH:27])=[CH:16][C:15]=2[F:28])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2].I[CH2:33][C:34]([NH2:36])=[O:35].C(=O)([O-])[O-].[Cs+].[Cs+].Cl.[NH2:44][OH:45]>CN(C=O)C>[C:34]([CH2:33][O:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:17]1[CH:16]=[C:15]([F:28])[C:14]([CH:10]([O:11][CH2:12][CH3:13])[C:9]([NH:8][CH2:7][C:6]2[CH:5]=[CH:4][C:3]([C:1](=[NH:2])[NH:44][OH:45])=[CH:31][CH:30]=2)=[O:29])=[C:19]([F:20])[CH:18]=1)(=[O:35])[NH2:36]