2-Bromobenzaldehyde → HCID 21904933, compound

HRID 1247410Notes

Reaction equation

[C:1]([C:3]1[CH:33]=[CH:32][C:6]([CH2:7][NH:8][C:9](=[O:31])[CH:10]([C:14]2[C:19]([F:20])=[CH:18][C:17](B3OC(C)(C)C(C)(C)O3)=[CH:16][C:15]=2[F:30])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2].Br[C:35]1[CH:42]=[CH:41][CH:40]=[CH:39][C:36]=1[CH:37]=[O:38]>>[C:1]([C:3]1[CH:33]=[CH:32][C:6]([CH2:7][NH:8][C:9](=[O:31])[CH:10]([C:14]2[C:15]([F:30])=[CH:16][C:17]([C:35]3[CH:42]=[CH:41][CH:40]=[CH:39][C:36]=3[CH:37]=[O:38])=[CH:18][C:19]=2[F:20])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2]

Participants

Reactant 2

HCID 811292-Bromobenzaldehyde

HCID 21905505HCID 21905505, compound

Product 1

HCID 21904933HCID 21904933, compound

Procedure

In analogy to example 262.2, (RS)-N-(4-cyano-benzyl)-2-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-2-ethoxy-acetamide (example 262.1) was reacted with 2-bromobenzaldehyde to give (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-formyl-biphenyl-4-yl)-2-ethoxy-acetamide. Off-white solid. MS 435.0 ([M+H]+)

Sources & evidence

ORD record: ord-51fa13b81e6d4bf0bd3390028dd82ad3
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

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