Phenylboronic Acid → HCID 21905067, compound

HRID 1247414Notes

Reaction equation

[C:1]([C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([CH:11]([O:27][CH3:28])[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2OS(C(F)(F)F)(=O)=O)=[O:10])=[CH:5][CH:4]=1)#[N:2].[C:31]1(B(O)O)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:1]([C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9](=[O:10])[CH:11]([C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[O:27][CH3:28])=[CH:5][CH:4]=1)#[N:2]

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 86593053HCID 86593053, compound

Product 1

HCID 21905067HCID 21905067, compound

Procedure

Using a similar procedure as described in example 57.1 (RS)-trifluoro-methanesulfonic acid 2-[(4-cyano-benzylcarbamoyl)-methoxy-methyl]-3-fluoro-phenyl ester (example 279.1) was reacted with phenyl boronic acid to give (RS)-N-(4-cyano-benzyl)-2-(3-fluoro-biphenyl-2-yl)-2-methoxy-acetamide. Solid. MS 375.3 ([M+H]+)

Sources & evidence

ORD record: ord-0414ccc115fe47bea7d02b0868242fb0
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

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