Phenylboronic Acid → HCID 21905504, compound

HRID 1247417Notes

Reaction equation

[C:1]([C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][C:9](=[O:23])[CH:10]([C:14]2[C:19]([F:20])=[CH:18][C:17]([OH:21])=[CH:16][C:15]=2[F:22])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2].[C:26]1(B(O)O)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9](=[O:23])[CH:10]([C:14]2[C:15]([F:22])=[CH:16][C:17]([O:21][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:18][C:19]=2[F:20])[O:11][CH2:12][CH3:13])=[CH:24][CH:25]=1)#[N:2]

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 21905325HCID 21905325, compound

Product 1

HCID 21905504HCID 21905504, compound

Procedure

In analogy to example 278.4 (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-hydroxy-phenyl)-2-ethoxy-acetamide (example 293.2) was reacted with phenyl boronic acid to give (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-phenoxy-phenyl)-2-ethoxy-acetamide. Light yellow solid. MS 423.1 ([M+H]+)

Sources & evidence

ORD record: ord-118cc95f23074c74ade8dbeea95180cd
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

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